非加热型湿房镜治疗干眼的临床疗效

目的评价湿房镜治疗干眼的临床疗效。方法自身对照临床研究。连续收集年11月至年6月期间在门诊就诊的轻中度干眼患者56例（56眼），填写干眼症状问卷、眼表疾病指数量表（OSDI）问卷，并进行眨眼频次、结膜充血程度、角膜荧光染色及泪液分泌试验（SIT）和泪膜破裂时间（BUT）测定。予配戴湿房镜1周后再次检查，内容同上。采用自身对照的配对t检验或秩和检验对治疗前后的数据进行统计学分析，并用秩和相关检验方法分析眼表保护指数（OPI）与角膜荧光染色的相关性。结果56例干眼患者配戴湿房镜1周后，干眼症状明显改善，其中干眼问卷评分（Z=-5.，P＜0.01）及OSDI问卷评分（Z=-5.，P＜0.01）较治疗前改善，差异有统计学意义；眨眼频次减少（t=6.，P0.01）；睑结膜充血（Z=-4.，P＜0.01）、球结膜充血（Z=-2.，P＜0.01）、角膜荧光染色（Z=-5.，P＜0.01）及体征总分（Z=-5.，P＜0.01）等临床体征评分明显降低，差异均有统计学意义；BUT明显增加（t=7.，P0.01），OPI明显增加（Z=-5.，P＜0.01），差异具统计学意义。OPI指数与角膜荧光染色评分呈负相关（r=-0.，P＜0.01）。结论湿房镜可有效缓解轻中度干眼患者主观症状，稳定泪膜，减轻临床体征，是干眼的有效治疗手段之一。

干眼病；湿房镜；症状和体征；治疗结果

Theclinicaleffectsofnon-heatingmoisturechamberglassesinthetreatmentofdryeye

ZhaoHui，LiuZuguo，XiaoXinye，ChenJingyao，LinZhirong，HeHui，YangWenzhao，HuJiaoyue.EyeInstituteofXiamenUniversity，XiamenEyeCenterofXiamenUniversity，FujianProvincialKeyLaboratoryofOphthalmologyandVisualScience，Xiamen，China

Correspondingauthor：LiuZuguo，Email：zuguoliu

ObjectiveToevaluatetheclinicaleffectsofmoisturechamberglassesinthetreatmentofdryeye.MethodsThiswasaself-controlledclinicalstudy.Fifty-sixoutpatientswithmildtomoderatedryeyewereenrolledfromNovembertoJune.Symptomswereevaluatedwithadryeyequestionnaire，theocularsurfacediseaseindex（OSDI）questionnaire，blinkfrequency，conjunctivalhyperemia，cornealfluoresceinstaining，SchirmerⅠtest（SIT），andtearfilmbreak-uptime（BUT）.Thesameexaminationswereperformedafter1weekoftreatmentwithmoisturechamberglasses.Self-controlledpairedttestsorranksumtestswereusedforstatisticalanalysisofthedatabeforeandaftertreatment.Thecorrelationbetweentheocularsurfaceprotectionindex（OPI）andcornealfluoresceinstainingwasanalyzedbyarankcorrelationtest.ResultsAfteroneweekoftreatmentwithmoisturechamberglasses，symptomsofdryeyehadimprovedsignificantlybasedonlowerscoresonthedryeyequestionnaire（Z=-5.，P0.01）andtheOSDIquestionnaire（Z=-5.，P0.01）.Meanwhile，blinkfrequencyreduced（t=6.，P0.01），palpebralconjunctivalhyperemia（Z=-4.，P0.01）andbulbarconjunctivalhyperemia（Z=-2.，P0.01）werealleviated，andthecornealstainingscore（Z=-5.，P0.01）andthesignsscore（Z=-5.，P0.01）weresignificantlyreduced.Inaddition，moisturechamberglassesresultedinalongerBUT（t=7.，P0.01）andhigherOPI（Z=-5.，P0.01）；OPIwaspositivelycorrelatedwithcornealfluoresceinstaining（r=-0.，P＜0.01）.ConclusionMoisturechamberglassescaneffectivelyimprovesubjectivesymptomsinmildtomoderatedryeyepatientsaswellasstabilizetearfilmandalleviateclinicalsigns.Itholdsgreatpotentialinthetreatmentofdryeye.

Xerophthalmia；Moisturechamberglasses；Symptomssigns；Treatmentout







































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